The PANDORA fellows will be trained in the following scientific and technological goals:
1. Assessing safety of some representative types of NP (e.g. iron, titanium, cerium oxide) on the immune defence capacity of living organisms (from plants to humans).
2. Identifying common mechanisms/markers of reactivity predictive of risk vs. safety.
3. Designing predictive in vitro assays to detect the immuno-risk of NP for the environment and human health.
The eleven ESRs will be all enrolled in PhD schools, and will be additionally trained in an overarching training programme that will include training-by-research, joint courses of technical, scientific, ethical and transferrable skills, active participation to public scientific events, and an intense intersectoral networking exchange plan.
To accomplish its mission, PANDORA’s research plan will be organized in two well-interconnected research Workpackages (WP1 and 2), supported by three additional Workpackages including training (WP3), dissemination and outreach activities (WP4) and management (WP5).
The eleven PhD students will work on Individual Research Projects well integrated in the two research Workpackages and interconnected among them.
WP1: NP impact on immune responses of environmental species WP1: NP impact on immune responses of environmental species:
Definition of the NP-immune interaction across species, and the influence of NP on anti-infective responses.
WP2: Assays and biomarkers of NP impact on immunity of environmental species WP2: Assays and biomarkers of NP impact on immunity of environmental species
Defining biomarkers of immunological risk and at developing predictive assays thereof.
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